Keisuke Goda
Mechanocytometry Session
Friday, October, 1st, 2021, 9:00am – 10:30am
Image-activated cell sorting and beyond
Professor, Department of Chemistry, University of Tokyo
Adjunct Professor, Institute of Technological Sciences, Wuhan University
Adjunct Professor, Department of Bioengineering, University of California, Los Angeles
Abstract
A fundamental challenge of biology is to understand the vast heterogeneity of cells, particularly how the spatial architecture of cells is linked to their physiological function. Unfortunately, conventional technologies are limited in uncovering these relations. In this talk, I introduce a new type of technology known as “Image-Activated Cell Sorting” that performs real-time image-based sorting of cells at an unprecedented rate. This technology integrates high-throughput cell microscopy, focusing, sorting, and computational analytics on a hybrid software-hardware data-management infrastructure, enabling real-time automated operation for data acquisition, data processing, intelligent decision-making, and actuation. I show several unique applications of the technology and introduce its recent upgrades.
Biosketch
Keisuke Goda is a professor in the Department of Chemistry at the University of Tokyo, an adjunct professor in the Institute of Technological Sciences at Wuhan University, and an adjunct professor in the Department of Bioengineering at UCLA. He obtained a B.A. degree from UC Berkeley summa cum laude in 2001 and a Ph.D. from MIT in 2007, both in physics. At MIT, he worked on the development of gravitational-wave detectors in the LIGO group which led to the 2017 Nobel Prize in Physics. After several years of work on high-speed imaging and microfluidics at Caltech and UCLA, he joined the University of Tokyo as a professor. His research group focuses on the development of serendipity-enabling technologies based on molecular imaging and spectroscopy together with microfluidics and computational analytics to push the frontier of science (http://www.goda.chem.s.u-tokyo.ac.jp). He currently leads Serendipity Lab, a global network of scientists who aim to achieve Louis Pasteur’s statement “Chance favors the prepared mind” (http://www.serendipitylab.org). He has published >300 papers, filed >30 patents, and received numerous awards and honors.
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Publications
Intelligent image-activated cell sorting